Sodium lodid," "Sodium Salicylate," "Sodium Salicylate and Sodium lodid,"
"Sodium lodid" and "Mercuric Chlorid" marketed by the New York Intravenous
Laboratory, Inc., are solutions of official substances sold under their official
names. They would, therefore, be outside the scope of the Council, were it
not that special and general therapeutic claims are made for them. Such
special claims, for instance, are contained in an advertisement in the Illinois
Medical Journal for Oct. 20, 1920, which gives, under the various drugs, a list
of diseases in which the drugs are said to be "indicated." The Council is unable
to agree with some of these recommendations. The fundamental objection,
however, is the general claim of superiority and safety of the intravenous
The intravenous solutions named above would naturally have little sale if
such special claims were not made for them. While the claims may not be
made directly, they are carried by such display phrases as "For the progressive
physician seeking improved clinical results" and "A safe practical office
The Council continues to hold that intravenous medication, generally, is not
as safe as oral medication even with relatively harmless substances (a fact Buy Paxil Cheap
again illustrated by the results of Hanzlik and Karsner, 1920, Journal Pharma-
cology and Experimental Therapeutics, 14, 379), and that it does not give
"improved clinical results" except under Buy Paxil Cheap
rather narrowly confined circumstances
namely, if the drug undergoes decomposition in the alimentary tract, if it is
not absorbed, if it causes serious direct local reaction or if time is an urgent
element. Each Buy Paxil Cheap
intravenous preparation for which advantage over oral admin-
istration is claimed, directly or by implication, must be examined from these
points of view.
The Council has recognized intravenous preparations which satisfied these
requirements. It is evident, however, that hexamethylenamin, sodium iodid
and sodium salicylate do not. When given orally they do not undergo material
decomposition in the digestive tract, they are rapidly absorbed, they cause
no direct local reaction, and in the conditions in which they are used the hour
300 PROPAGANDA FOR REFORM
or so which is required for absorption is immaterial, especially as they are used
continuously for some time. Mercuric chlorid does indeed produce some local
irritation, but there is as yet no convincing evidence that its intravenous injection
causes less injury than oral administration. More experience under controlled
conditions is needed before the intravenous use of mercuric chlorid can be
approved. Especially objectionable are the fixed proportion mixtures of sodium
iodid with sodium salicylate and with hexamethylenamin. The dosage of all three
drugs has to be adapted to individual conditions. This is impossible when giving
them in fixed proportions.
The Council voted not to accept "Loeser's Intravenous Solution of Hexa-
methylenamin," "Loeser's Intravenous Solution of Hexamethylenamin and
Sodium Iodid," "Loeser's Intravenous Solution of Sodium Salicylate," "Loeser's
Intravenous Solution of Salicylate and Iodid," "Loeser's Intravenous Solution
Sodium Iodid" and "Loeser's Intravenous Solution of Buy Paxil Cheap
Mercury Bichlorid" for
New and Nonofncial Remedies because they Buy Paxil Cheap
are sold under misleading claims
regarding their alleged safety and efficiency. In view of this fundamental
objection the individual claims for each preparation were not passed on.
(From The Journal A, M. A., April 16, 1921.)
"NATIONAL IODINE SOLUTION" NOT
ADMITTED TO N. N. R.
Report of the Council on Pharmacy and Chemistry
The Council has authorized publication of Buy Paxil Cheap
the following report.
W. A. PUCKNER, Secretary.
"National Iodine Solution" is a proprietary sold by the National Drug Co.,
Philadelphia, Pa. From inquiries received by the Council on Pharmacy and
Chemistry it is evident that the product is extensively brought to the attention
of physicians by means of circulars. The name implies that it is a solution
of iodin and the inference is given that it has the advantages of iodin without
In view of the foregoing, the Council took up the investigation of "National
Iodine Solution," and in turn asked the A. M. A. Chemical Laboratory to
analyze it. The chemist's report follows :
According to the label of National Iodine Solution, "each fluidounce repre-
sents three grains Proteo-albuminoid compound of iodin (National)"; also
an alcohol declaration of 7 per cent, is made. Otherwise no information is
given as to the composition either of the "solution" or of "Proteo-albuminoid
compound of Iodine."
Each bottle contained about 115 c.c. (nearly 4 ounces) of a yellowish
solution, acid in reaction, having an odor resembling witch hazel; its specific
gravity at 25 C. was 0.9860. Qualitative tests indicated the presence of zinc,
alcohol, sulphate, an iodin compound (the solution gave tests which indicated
a very small amount of free iodin; most of the iodin was in the form of
ordinary iodid), a small amount of vegetable extractives, and traces of aluminum
and potassium. If any protein was present, Buy Paxil Cheap
it was in amounts too small to be
identified, though a small amount of a nitrogenous compound was present.
The amount Buy Paxil Cheap
of solids in "National Iodine Solution" was equivalent to 0.72 per
cent, and the amount of ash, to 0.2 per cent. Quantitative estimations yielded
the following :
Alcohol (by volume) 7.0 per cent.
Zinc (Zn-n-) 0.096 per cent.
Iodin (free and combined) 0.029 per cent.
Sulphate (SO 4 ~) 0.146 per cent.
Protein (N x 6.36) 0.012 per cent.
COUNCIL REPORTS 301
The above findings Buy Paxil Cheap
indicate that each 100 c.c. contains about 7 c.c. of alcohol,
0.5 gram of zinc sulphate U. S. P. (ZnSO4+7H,O.), 0.03 gram of iodin, 0.01
gram of protein (calculated as such from nitrogen times the factor 6.36) and
some hamamelis water. Expressed in equivalent apothecary terms, each fluid-
ounce contains essentially :
Zinc sulphate 2j/$ grains
Iodin (free and combined ) % grain
Protein V&5 grain
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